My personal keyboard setup, a mixture of the old and the new.
This setup retains some elements from the early days of Opera, e.g. to make a new tab you press ctrl+n, to duplicate a tab, you press ctrl+shift+n. Hiding Opera in the system tray is done with the simple ctrl+h instead of the finger wrenching thing that's the present default. Showing and hiding the menu bar can be done with alt+f11.
On the other hand, since it is based on a new keyboard.ini file, there is also support for the speeddial shortcuts.